C. Guillen
Det
Homeruns
| Game Date | Season # | Opp. | Pitcher | Inning | B | S | O | Runners | Com. |
| September 30th | 21 | CWS | Contreras | 3 | 1 | 1 | 1 | 1 | 0 |
| September 29th | 20 | CWS | Floyd | 6 | 3 | 1 | 2 | 0 | 0 |
| August 26th | 19 | NYY | Hughes | 1 | 3 | 1 | 2 | 1 | 0 |
| August 24th | 18 | NYY | Henn | 11 | 1 | 2 | 2 | 2 | 0 |
| August 22nd | 17 | Cle | Byrd | 1 | 1 | 1 | 2 | 2 | 0 |
| August 21st | 16 | Cle | Carmona | 5 | 1 | 1 | 0 | 0 | 0 |
| August 16th | 15 | NYY | Mussina | 1 | 2 | 2 | 1 | 3 | 0 |
| July 8th | 14 | Bos | Matsuzaka | 3 | 2 | 1 | 1 | 1 | 0 |
| July 5th | 13 | Cle | Sabathia | 3 | 0 | 2 | 1 | 2 | 0 |
| June 23rd | 12 | Atl | Davies | 4 | 1 | 0 | 0 | 0 | 0 |
| June 20th | 11 | Was | Bacsik | 4 | 0 | 2 | 1 | 1 | 0 |
| June 18th | 10 | Was | Chico | 4 | 1 | 1 | 0 | 0 | 0 |
| August 16th | 10 | Bal | Sarfate | 4 | 0 | 0 | 1 | 0 | 0 |
| June 16th | 9 | Phi | Moyer | 2 | 0 | 1 | 0 | 0 | 0 |
| July 25th | 9 | CWS | Masset | 7 | 2 | 0 | 1 | 0 | 0 |
| June 9th | 8 | NYM | Perez | 1 | 1 | 2 | 2 | 2 | 0 |
| July 5th | 8 | Sea | Dickey | 1 | 3 | 2 | 2 | 0 | 0 |
| June 6th | 7 | Tex | Littleton | 5 | 1 | 1 | 0 | 0 | 0 |
| June 25th | 7 | StL | Lohse | 4 | 2 | 2 | 2 | 2 | 0 |
| May 24th | 6 | LAA | Bootcheck | 6 | 0 | 0 | 0 | 1 | 0 |
| June 7th | 6 | Cle | Laffey | 4 | 3 | 1 | 2 | 1 | 0 |
| May 24th | 5 | LAA | Santana | 1 | 1 | 0 | 1 | 2 | 0 |
| May 25th | 5 | Min | Perkins | 2 | 1 | 1 | 2 | 0 | 0 |
| May 23rd | 4 | LAA | Colon | 3 | 0 | 1 | 0 | 0 | 0 |
| May 20th | 4 | Sea | Lowe | 7 | 0 | 0 | 0 | 0 | 0 |
| May 11th | 3 | Min | Rincon | 9 | 1 | 0 | 1 | 1 | 0 |
| April 15th | 3 | Min | Baker | 7 | 2 | 0 | 0 | 0 | 0 |
| April 21st | 2 | CWS | Contreras | 1 | 0 | 0 | 1 | 3 | 0 |
| April 9th | 2 | Bos | Lopez | 9 | 0 | 1 | 2 | 0 | 0 |
| April 16th | 1 | KC | Standridge | 4 | 2 | 0 | 0 | 0 | 0 |
| March 31st | 1 | KC | Tomko | 8 | 2 | 1 | 0 | 0 | 0 |