C. Granderson
Det
Homeruns
| Game Date | Season # | Opp. | Pitcher | Inning | B | S | O | Runners | Com. |
| September 22nd | 23 | KC | Davies | 1 | 1 | 1 | 0 | 0 | 0 |
| September 16th | 22 | Min | Baker | 1 | 3 | 1 | 0 | 0 | 0 |
| September 28th | 22 | TB | Talbot | 3 | 2 | 1 | 1 | 2 | 0 |
| September 9th | 21 | Sea | Hernandez | 2 | 1 | 0 | 1 | 0 | 0 |
| September 25th | 21 | TB | Bradford | 7 | 1 | 2 | 2 | 0 | 0 |
| September 7th | 20 | Sea | Batista | 7 | 3 | 1 | 1 | 0 | 0 |
| September 20th | 20 | Cle | Perez | 7 | 3 | 2 | 2 | 1 | 0 |
| September 1st | 19 | Oak | Haren | 3 | 2 | 2 | 0 | 0 | 0 |
| September 14th | 19 | CWS | Logan | 8 | 2 | 2 | 0 | 0 | 0 |
| August 30th | 18 | KC | Nunez | 5 | 3 | 1 | 1 | 0 | 0 |
| September 6th | 18 | Min | Reyes | 8 | 1 | 1 | 1 | 1 | 0 |
| August 26th | 17 | NYY | Hughes | 1 | 1 | 2 | 0 | 0 | 0 |
| September 4th | 17 | LAA | Santana | 8 | 2 | 0 | 1 | 0 | 0 |
| July 27th | 16 | LAA | Weaver | 4 | 2 | 2 | 2 | 0 | 0 |
| August 27th | 16 | Cle | Carmona | 1 | 2 | 2 | 0 | 0 | 0 |
| July 24th | 15 | CWS | Vazquez | 6 | 2 | 2 | 0 | 0 | 0 |
| August 10th | 15 | Oak | Smith | 5 | 0 | 1 | 0 | 0 | 0 |
| July 23rd | 14 | CWS | Buehrle | 1 | 0 | 0 | 0 | 0 | 0 |
| August 7th | 14 | CWS | Vazquez | 7 | 0 | 1 | 0 | 0 | 0 |
| July 14th | 13 | Sea | Batista | 1 | 2 | 1 | 0 | 0 | 0 |
| August 5th | 13 | CWS | Floyd | 5 | 1 | 2 | 0 | 1 | 0 |
| July 6th | 12 | Bos | Tavarez | 5 | 0 | 0 | 0 | 0 | 0 |
| August 3rd | 12 | TB | Percival | 9 | 0 | 0 | 0 | 0 | 0 |
| June 30th | 11 | Min | Slowey | 5 | 1 | 2 | 0 | 0 | 0 |
| July 27th | 11 | CWS | Vazquez | 3 | 1 | 1 | 0 | 0 | 0 |
| June 26th | 10 | Tex | Eyre | 5 | 2 | 1 | 1 | 0 | 0 |
| July 12th | 10 | Min | Baker | 8 | 3 | 1 | 0 | 1 | 0 |
| June 16th | 9 | Phi | Moyer | 3 | 3 | 2 | 1 | 0 | 0 |
| June 20th | 9 | SD | Maddux | 1 | 1 | 1 | 0 | 0 | 0 |
| May 23rd | 8 | LAA | Oliver | 8 | 1 | 2 | 0 | 0 | 0 |
| June 8th | 8 | Cle | Sowers | 2 | 3 | 2 | 2 | 0 | 0 |
| May 14th | 7 | Bos | Matsuzaka | 3 | 2 | 1 | 2 | 0 | 0 |
| June 2nd | 7 | Oak | Harden | 6 | 3 | 2 | 0 | 0 | 0 |
| May 9th | 6 | Sea | Baek | 1 | 1 | 2 | 0 | 0 | 0 |
| May 20th | 6 | Sea | Baek | 6 | 1 | 0 | 0 | 1 | 0 |
| May 6th | 5 | KC | Greinke | 2 | 1 | 2 | 2 | 1 | 0 |
| May 4th | 5 | Min | Bonser | 1 | 2 | 1 | 0 | 0 | 0 |
| April 24th | 4 | LAA | Speier | 7 | 1 | 1 | 1 | 0 | 0 |
| May 3rd | 4 | Min | Neshek | 8 | 3 | 2 | 2 | 0 | 0 |
| April 23rd | 3 | LAA | Weaver | 1 | 2 | 2 | 0 | 0 | 0 |
| April 29th | 3 | NYY | Hughes | 3 | 1 | 1 | 0 | 0 | 0 |
| April 7th | 2 | KC | Meche | 5 | 2 | 0 | 0 | 0 | 0 |
| April 25th | 2 | LAA | Santana | 4 | 3 | 1 | 0 | 0 | 0 |
| April 4th | 1 | Tor | Marcum | 3 | 0 | 1 | 2 | 3 | 0 |
| April 24th | 1 | Tex | Jennings | 1 | 3 | 2 | 0 | 0 | 0 |