J. Guillen
Sea
Homeruns
| Game Date | Season # | Opp. | Pitcher | Inning | B | S | O | Runners | Com. |
| September 27th | 23 | Cle | Byrd | 1 | 1 | 2 | 2 | 1 | 0 |
| September 26th | 22 | Cle | Carmona | 1 | 1 | 2 | 2 | 1 | 0 |
| September 21st | 21 | LAA | Thompson | 8 | 1 | 1 | 0 | 0 | 0 |
| September 10th | 20 | Oak | Embree | 8 | 0 | 0 | 1 | 0 | 0 |
| September 12th | 20 | Cle | Lee | 9 | 0 | 0 | 0 | 0 | 0 |
| August 24th | 19 | Tex | Millwood | 1 | 2 | 0 | 2 | 0 | 0 |
| September 12th | 19 | Cle | Lee | 6 | 0 | 2 | 1 | 0 | 0 |
| August 23rd | 18 | Tex | Loe | 6 | 0 | 1 | 0 | 0 | 0 |
| August 31st | 18 | Det | Galarraga | 6 | 0 | 0 | 0 | 0 | 0 |
| August 19th | 17 | CWS | Garland | 1 | 0 | 0 | 1 | 1 | 0 |
| August 24th | 17 | Det | Rogers | 2 | 0 | 0 | 0 | 0 | 0 |
| August 12th | 16 | CWS | Danks | 5 | 1 | 1 | 1 | 0 | 0 |
| August 3rd | 16 | CWS | Richard | 3 | 1 | 1 | 1 | 0 | 0 |
| August 9th | 15 | Bal | Cabrera | 3 | 2 | 2 | 1 | 0 | 0 |
| August 2nd | 15 | CWS | Buehrle | 4 | 1 | 1 | 2 | 0 | 0 |
| August 8th | 14 | Bal | Guthrie | 4 | 0 | 0 | 2 | 1 | 0 |
| July 28th | 14 | Oak | Braden | 1 | 0 | 0 | 2 | 1 | 0 |
| July 27th | 13 | Oak | Braden | 4 | 3 | 2 | 2 | 1 | 0 |
| June 23rd | 13 | Col | Francis | 3 | 1 | 0 | 1 | 0 | 0 |
| July 15th | 12 | Det | Miner | 9 | 0 | 0 | 2 | 1 | 0 |
| June 21st | 12 | SF | Sadler | 7 | 2 | 1 | 1 | 1 | 0 |
| July 13th | 11 | Det | Bonderman | 2 | 1 | 1 | 0 | 0 | 0 |
| June 9th | 11 | NYY | Rivera | 9 | 0 | 2 | 0 | 0 | 0 |
| July 1st | 10 | Tor | Janssen | 8 | 0 | 0 | 0 | 0 | 0 |
| June 8th | 10 | NYY | Chamberlain | 3 | 3 | 2 | 2 | 1 | 0 |
| June 16th | 9 | Hou | Williams | 6 | 2 | 1 | 0 | 0 | 0 |
| June 7th | 9 | NYY | Pettitte | 7 | 2 | 2 | 2 | 3 | 0 |
| June 12th | 8 | ChC | Hill | 3 | 0 | 0 | 1 | 0 | 0 |
| June 7th | 8 | NYY | Pettitte | 1 | 2 | 1 | 2 | 1 | 0 |
| June 2nd | 7 | Tex | Loe | 6 | 0 | 0 | 0 | 0 | 0 |
| June 1st | 7 | Cle | Byrd | 2 | 0 | 1 | 0 | 0 | 0 |
| May 28th | 6 | LAA | Colon | 1 | 0 | 0 | 2 | 0 | 0 |
| May 22nd | 6 | Bos | Hansen | 7 | 0 | 1 | 0 | 0 | 0 |
| May 19th | 5 | SD | Maddux | 1 | 0 | 1 | 1 | 1 | 0 |
| May 18th | 5 | Fla | Kensing | 7 | 3 | 1 | 1 | 1 | 0 |
| May 9th | 4 | Det | Robertson | 4 | 0 | 0 | 1 | 2 | 0 |
| May 15th | 4 | Det | Rogers | 4 | 0 | 0 | 2 | 0 | 0 |
| May 2nd | 3 | CWS | Danks | 2 | 0 | 0 | 1 | 0 | 0 |
| April 29th | 3 | Tex | Feldman | 4 | 1 | 2 | 0 | 1 | 0 |
| April 25th | 2 | Oak | Blanton | 2 | 1 | 1 | 2 | 0 | 0 |
| April 26th | 2 | Tor | Marcum | 6 | 2 | 2 | 0 | 0 | 0 |
| April 14th | 1 | Tex | Wilson | 7 | 1 | 0 | 1 | 1 | 0 |
| April 19th | 1 | Oak | Smith | 1 | 0 | 1 | 2 | 2 | 0 |