D. Pedroia
Bos
Homeruns
| Game Date | Season # | Opp. | Pitcher | Inning | B | S | O | Runners | Com. |
| September 3rd | 17 | Bal | Walker | 7 | 0 | 1 | 1 | 0 | 0 |
| September 2nd | 16 | Bal | Cabrera | 4 | 1 | 1 | 1 | 2 | 0 |
| August 27th | 15 | NYY | Robertson | 8 | 2 | 0 | 1 | 3 | 0 |
| August 24th | 14 | Tor | Burnett | 3 | 0 | 0 | 2 | 2 | 0 |
| August 22nd | 13 | Tor | Marcum | 1 | 1 | 1 | 1 | 0 | 0 |
| August 17th | 12 | Tor | Carlson | 7 | 2 | 2 | 2 | 0 | 0 |
| August 16th | 11 | Tor | Halladay | 9 | 0 | 0 | 0 | 0 | 0 |
| August 8th | 10 | CWS | Dotel | 8 | 2 | 2 | 1 | 2 | 0 |
| July 2nd | 9 | TB | Kazmir | 1 | 2 | 2 | 1 | 0 | 0 |
| September 26th | 8 | Oak | Blevins | 6 | 2 | 0 | 0 | 0 | 0 |
| June 29th | 8 | Hou | Moehler | 3 | 1 | 0 | 0 | 0 | 0 |
| September 11th | 7 | TB | Switzer | 6 | 1 | 1 | 0 | 0 | 0 |
| June 24th | 7 | Ari | Davis | 1 | 3 | 2 | 1 | 0 | 0 |
| August 17th | 6 | LAA | Jones | 8 | 2 | 2 | 1 | 0 | 0 |
| June 16th | 6 | Phi | Hamels | 5 | 3 | 1 | 1 | 0 | 0 |
| August 8th | 5 | LAA | Speier | 7 | 1 | 1 | 0 | 0 | 0 |
| June 15th | 5 | Cin | Majewski | 6 | 1 | 2 | 1 | 0 | 0 |
| July 16th | 4 | KC | Bannister | 4 | 3 | 2 | 1 | 0 | 0 |
| May 31st | 4 | Bal | Olson | 3 | 3 | 2 | 2 | 0 | 0 |
| June 15th | 3 | SF | Zito | 1 | 1 | 0 | 0 | 1 | 0 |
| May 23rd | 3 | Oak | Harden | 4 | 2 | 1 | 1 | 0 | 0 |
| October 19th | 3 | TB | Garza | 1 | 1 | 1 | 1 | 0 | 0 |
| May 27th | 2 | Tex | Gagne | 9 | 2 | 2 | 0 | 0 | 0 |
| October 24th | 2 | Col | Francis | 1 | 0 | 1 | 0 | 0 | 0 |
| May 18th | 2 | Mil | Villanueva | 3 | 1 | 1 | 2 | 0 | 0 |
| October 11th | 2 | TB | Kazmir | 5 | 1 | 0 | 0 | 0 | 0 |
| May 8th | 1 | Tor | Zambrano | 2 | 1 | 1 | 2 | 2 | 0 |
| October 21st | 1 | Cle | Betancourt | 7 | 0 | 1 | 1 | 1 | 0 |
| April 18th | 1 | Tex | Rupe | 4 | 0 | 1 | 1 | 1 | 0 |
| October 11th | 1 | TB | Kazmir | 3 | 3 | 2 | 0 | 0 | 0 |